Furthermore, many clinicians are co-administering ketamine or fentanyl in conjunction. Maintenance: 100 to 200 mcg/kg/min with a maximum dose of 20,000 mcg/min. Much research has since demonstrated its safety in adults and children. Propofol (10 mg/mL) (1 - 8 mg/kg) Robenacoxib (20 mg/mL) (2 mg/kg) Tiletamine/ zolazepam (100 mg/mL) (1 - 4 mg/kg) EQUIPMENT AND SUPPLIES: Breathing Circuit. A brief description of propofol … Neurosurgery: Induction: 20 mg every 10 seconds until induction onset (1 to 2 mg/kg). This table is based on field study results and is for guidance only. Maximum dose of 15,000 mcg/min. 240 mg become the dose ordered, 10 mg is the dose available, 1 mL is the volume available. Propofol Dosage and Administration. Anesthesia was induced with a median propofol dose of 1.4 mg/kg (range: 0.9 to 6.9 mg/kg) and maintained with a median maintenance propofol dose of 146 mcg/kg/min (range: 68 to 425 mcg/kg/min). The structural formula is: C 12 H 18 O M.W. 240/10 x 1 = 24. Propofol blood concentrations at steady-state are generally proportional to infusion rates, especially in individual patients. Methods. There is a lack of intensive care unit (ICU) studies assessing the accumulation of propofol in obese patients that are mechanically ventilated receiving long-term sedation. Propofol is slightly soluble in water and, thus, is formulated in a white, oil-in-water Pre=treatment–’agentsshouldbe’given3minutespriortointubation ’(canbe’ giveninanyorder)’ Drug’ Dose’ Indication’ Other’notes’ The answer is 24 mL/hr. 100 to 150 mcg/kg/min (primary propofol) 50 to 100 mcg/kg/min (secondary propofol). The median duration of the propofol maintenance infusion was … The last American College of Emergency Physicians (ACEP) guideline recommendations regarding the use of propofol for ED procedural sedation was in 2007. The dose and rate for propofol … (propofol) injectable emulsion, USP is a sterile, nonpyrogenic emulsion containing 10 mg/mL of propofol suitable for intravenous administration. It is the responsibility of the providing veterinarian to decide drug dosages for an … 178.27 . Propofol is available in 10mg/ml concentration in 20 ml, 50 ml and 100 ml bottles. Maintenance Dosage Guidelines Preanesthetic* Propofol Maintenance Dose Propofol Rate of Administration mg/kg Seconds mg/kg/ min mL/kg/ min None 3.2 60 3.2 0.32 Benzodiazepine/ Opioid 1.7 60 1.7 0.17 Phenothiazine/ Opioid 2.0 60 2.0 0.20 *Doses for preanesthetics may be lower than the label directions for their use as a single medication2. The aim of the study was to develop propofol dosing guidelines for ICU sedation based on an integrated pharmacokinetic-pharmacodynamic model of propofol infusions in ICU patients. Dosing Information of Propofol for Dogs and Cats; Propofol is dosed at 1.5 to 4 mg per pound (3 to 8 mg/kg) intravenous, given slowly over 1 minute. Propofol is chemically described as 2,6-diisopropylphenol. Background: Propofol is a lipophilic medication shown in pharmacokinetic studies to accumulate over time and potentially cause over sedation in obese patients when dosing is based on total body weight. The average PropoFlo™ 28 induction dose rates for healthy dogs given propofol alone, or when propofol is preceded by a preanesthetic, are indicated in the table below. Undesirable effects such as cardiorespiratory depression are likely to occur at higher blood concentrations which result from bolus dosing or rapid increases in the infusion rate. For constant infusion, propofol is dosed at 0.05 to 0.3 mg per pound per minute (0.1 to 0.6 mg/kg/min). Dosed at 0.05 to 0.3 mg per pound per minute ( 0.1 to 0.6 mg/kg/min ) in conjunction on study! 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