The average PropoFlo™ 28 induction dose rates for healthy dogs given propofol alone, or when propofol is preceded by a preanesthetic, are indicated in the table below. Propofol (10 mg/mL) (1 - 8 mg/kg) Robenacoxib (20 mg/mL) (2 mg/kg) Tiletamine/ zolazepam (100 mg/mL) (1 - 4 mg/kg) EQUIPMENT AND SUPPLIES: Breathing Circuit. 240/10 x 1 = 24. The median duration of the propofol maintenance infusion was … The last American College of Emergency Physicians (ACEP) guideline recommendations regarding the use of propofol for ED procedural sedation was in 2007. This table is based on field study results and is for guidance only. For constant infusion, propofol is dosed at 0.05 to 0.3 mg per pound per minute (0.1 to 0.6 mg/kg/min). Background: Propofol is a lipophilic medication shown in pharmacokinetic studies to accumulate over time and potentially cause over sedation in obese patients when dosing is based on total body weight. Propofol is chemically described as 2,6-diisopropylphenol. Maintenance Dosage Guidelines Preanesthetic* Propofol Maintenance Dose Propofol Rate of Administration mg/kg Seconds mg/kg/ min mL/kg/ min None 3.2 60 3.2 0.32 Benzodiazepine/ Opioid 1.7 60 1.7 0.17 Phenothiazine/ Opioid 2.0 60 2.0 0.20 *Doses for preanesthetics may be lower than the label directions for their use as a single medication2. 240 mg become the dose ordered, 10 mg is the dose available, 1 mL is the volume available. Propofol is available in 10mg/ml concentration in 20 ml, 50 ml and 100 ml bottles. Much research has since demonstrated its safety in adults and children. The answer is 24 mL/hr. Neurosurgery: Induction: 20 mg every 10 seconds until induction onset (1 to 2 mg/kg). 178.27 . Maximum dose of 15,000 mcg/min. Furthermore, many clinicians are co-administering ketamine or fentanyl in conjunction. Maintenance: 100 to 200 mcg/kg/min with a maximum dose of 20,000 mcg/min. Undesirable effects such as cardiorespiratory depression are likely to occur at higher blood concentrations which result from bolus dosing or rapid increases in the infusion rate. It is the responsibility of the providing veterinarian to decide drug dosages for an … Pre=treatment–’agentsshouldbe’given3minutespriortointubation ’(canbe’ giveninanyorder)’ Drug’ Dose’ Indication’ Other’notes’ Propofol Dosage and Administration. 100 to 150 mcg/kg/min (primary propofol) 50 to 100 mcg/kg/min (secondary propofol). There is a lack of intensive care unit (ICU) studies assessing the accumulation of propofol in obese patients that are mechanically ventilated receiving long-term sedation. Methods. The structural formula is: C 12 H 18 O M.W. The aim of the study was to develop propofol dosing guidelines for ICU sedation based on an integrated pharmacokinetic-pharmacodynamic model of propofol infusions in ICU patients. 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